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Being energized by ATP hydrolysis, they translocate heavy metals (Zn, Co, Cu, Cd, and Pb) out of cytoplasm (to plasma membrane and into vacuole) and thus play important roles in their transport, compartmentalization, and detoxification (Williams et al., 2000
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Nonetheless, tumor cells that endure radiation exposure concurrently activate a variety of pro-survival signaling pathways, such as ATM, ATR, AKT, ERK and NF-κB-mediated DNA damage checkpoints, DNA damage repair, inhibition of apoptosis, and cancer stem cell-related stem-like pathways
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