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Elevated serum copper levels are often observed in these patients due to the release of copper-containing enzymes after myocardial injury or because sympathetic nerves promote the release of copper from liver stores into the bloodstream during stress (54)

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Funding Research projects conducted by the authors on kratom alkaloids are funded by the Ministry of Higher Education Malaysia under Fundamental Research Grant Scheme with project codes: FRGS/1/2019/STG05/USM/02/1 and FRGS/1/2020/STG01/USM/02/10, and Universiti Sains Malaysia Short Term Grant (304/CDADAH/6315457)