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Further inspection of site-specific overlaps between aging and USP7 inhibition revealed increased ubiquitylation of proteins involved in the chaperone system (HSP90AA1, HSPH1, PPIA, SGTA), the ubiquitin-proteasome system (ATXN3, MINDY2, PSMB2, PSMD2, RAD23B, UBA1, UBXN1), cytoskeletal organization (ACTR1A, CORO2B, DCTN2, DCTN3, DYNC1H1, DYNLL1, MAP1B), and trafficking and sorting (AP2A1, CLTC, EPN1, EPN2) (Fig
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“Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.” Growth Hormone and IGF Research
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