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Growth factor binding to the respective GF receptor at the cell surface promotes the activation of PI3K (phosphoinositide 3-kinase) and PDK1, with the latter directly phosphorylating Akt (Hoxhaj and Manning, 2020)
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In early malignant transformation, mitophagy acts as a tumor-suppressor by removing damaged mitochondria (major sources of ROS) [229], thereby reducing oxidative stress and preventing genomic instability [230]
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