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Discussion Discovery of molecular glue degraders that co-opt E3 ligases beyond a few well-characterized E3 ligases remains challenging, as it requires unbiased strategies to identify compounds that induce proximity between an E3 ligase and a neo-substrate without prior knowledge of their interaction while sampling vast chemical space
circulation
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3.1.2 Hepatic First-Pass Metabolism Even if a small amount of GSH enters the bloodstream, it will be quickly taken up and metabolized by the liver
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