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IGF1-, IGFBP3-, and IGF1/IGFBP3 molar ratio-SDS In the leptin-deficient state, all patients had low IGF1 levels and IGF1/IGFBP3 molar ratios, as signified by negative values of IGF1-SDS (\(\overline x\) T0 : −1.58 ± 0.92, range −2.92 to −0.23) and IGF1/IGFBP3 molar ratio-SDS (\(\overline x\) T0 : −1.58 ± 0.88, range −3.15 to −0.44)