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For critically ill patients, clinicians may consider adjusting the escalation or tapering of analgesic regimens on the basis of individual needs, especially in those experiencing severe pain or presenting contraindications to nonsteroidal anti-inflammatory drugs

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Nausea severity peaks during the titration phase (weeks 1–8) because amylin receptor density in the area postrema is high and initial agonism triggers emetic signalling before downregulation occurs