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Although the number of therapeutic options for HCC has gradually increased in recent decades, including surgical resection, immunotherapy, targeted therapy, or combination therapy, overall survival and prognosis remain limited due to the lack of specific symptoms in the early stages of the disease and the loss of therapeutic opportunities (2)

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The combined GLP-1/GIP activation in tirzepatide creates a synergistic effect on appetite and glucose control that exceeds what either receptor alone could produce