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The barrier function is established by the lack of fenestrae in the vessels, the tight junctions connecting the endothelial cells, which prevent the paracellular route for external agents, and the low level of transcytotic vesicles (Rodrigues and Granger, 2015)
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Thus, women have a higher incidence of sex-related diseases but generate a more effective response against extracellular infections by having more antibodies (Th2 response) [209]
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