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Backbone-cyclized analogues with fewer disulfide bonds have been reported, but these often lack structural integrity and are likely to show compromised activity

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Nationally, transplant is considered an emergency procedure in patients that meet the criteria, and currently, one and 5-year post-transplant survival is 90 and 80%, respectively, with results becoming comparable to the population undergoing transplant for a chronic liver disease.6,7 A sudden decline in liver function, known as acute-on-chronic liver failure, is often misinterpreted in patients with chronic liver disease