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Regardless of its origin, vitamin D undergoes two steps: first, in the liver, it is hydroxylated by 25-hydroxylase (CYP2R1) to form 25-hydroxyvitamin D₃ [25(OH)D₃], and subsequently, in the kidney, it is hydroxylated by 1α-hydroxylase (CYP27B1) to generate the biologically active form, 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] (6)
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