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The groups that received the riboflavin-fortified salt had lower rates of esophageal cancer.[ref] Inflammatory Bowel Disease (IBD): In patients with Crohn’s disease, riboflavin (100mg/day) decreased inflammatory markers significantly in three weeks.[ref] Related article: IBD and Genetic Connections Inflammation: A randomized, placebo-controlled trial of supplemental riboflavin found that it reduced inflammation based on a lower CRP level.[ref] Related article : Inflammation and chronic disease Sleep quality: A 2025 randomized, double-blind, placebo-controlled trial found that supplementing with 100mg of vitamin B1 and 100mg vitamin B2 enhanced sleep quality and reduced stress