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Imbalance between antioxidant defenses and reactive oxygen species... | Download Scientific Diagram

2.1.2 Excessive production of mtROS Mitochondrial complexes are the main producers of mtROS (Yin et al., 2021), and the excessive production of mtROS and inhibition of antioxidase cause an imbalance in redox reactions (Springo et al., 2015), which promotes mtDNA mutations (Fontana and Gahlon, 2020), aggravates NF-κB activation (Csiszar et al., 2014), excites NAD(P)H oxidase (NOX) in the cytoplasm (Cho et al., 2013) determined that mtROS significantly increased and augmented superoxide dismutase 2 (SOD2) ubiquitination in coronary endothelial cells (ECs) from type 2 diabetic mice, leading to abnormal vascular relaxation and EC damage

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Ricinus communis Seed Oil