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In the SYSUCC-002 study, endocrine therapy combined with trastuzumab demonstrates efficacy not inferior to that of chemotherapy combined with trastuzumab, while also reducing the toxic side effects associated with chemotherapy and improving patient compliance

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Activation of the polyol pathway depletes NADPH, leading to AGEs binding to their receptors on cell surfaces, resulting in oxidative stress, ROS generation, and activation of PKC and ERK1/2 signaling pathways, ultimately promoting TGF-β secretion, mesangial cell proliferation, and ECM synthesis, culminating in renal fibrosis [73]