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Secondly, previous studies have reported that DUSP1 can alleviate inflammation by improving mitochondrial engulfment and metabolism [25], and we cannot rule out the possibility that the beneficial effect of DUSP1 in AKI-CKD may partly come from the regulation of mitochondrial engulfment and metabolism

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For peripheral nerve analysis, a 5-mm-long piece of tail 15 mm distal from the tail base was collected from each sacrificed animal, fixed in 4% formaldehyde in phosphate buffer (pH 7.4), decalcinated, and impregnated with 1% osmium tetroxide for a few days