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Concurrently, mitochondrial dysfunction and oxidative stress exacerbate inflammaging via mitochondrial reactive oxygen species (mtROS), which not only trigger NLRP3 inflammasome activation and IL-1β maturation but also suppress SIRT1 deacetylase activity, further reinforcing NF-κB-driven inflammatory cascades 43
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doi: 10.1083/jcb.201308006 124 CogliatiSFrezzaCSorianoMEVaranitaTQuintana-CabreraRCorradoMet al
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