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The most common modifications induced by ROS in the DNA are -oxo-7,8-dihydroguanine (8-oxoGua) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine, which lead to the production of apurinic/apyrimidinic (abasic) DNA sites, to oxidized purines and pyrimidines and to single-strand DNA breaks (SSBs) and DSBs (89, 100), finally inducing genetic instability and the possible emergence of brain tumors (89)
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