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In order to collect a sufficient number of cells for implantation, isolated chondrocytes usually undergo an extensive expansion from 0.1–0.2 million to 40–60 million… cultured chondrocytes gradually lose the proliferative capacity and the potential of generating the cartilage-specific matrix, a phenomenon known as dedifferentiation
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The topic becomes much more relevant when symptoms last longer than expected, feel stronger over time, or appear alongside a more complicated medical picture
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