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So, while you absorb over 50 per cent of a one microgram dose, you might only absorb 16 per cent of 10 micrograms, three per cent of 50 micrograms, two per cent of 500 micrograms and just 1.3 per cent of 1,000 micrograms
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2 Mechanisms of action 2,3 CD38-directed therapies work through multiple mechanisms, including: Complement-dependent cytotoxicity (CDC) Antibody-dependent cell-mediated cytotoxicity (ADCC) Antibody-dependent cellular phagocytosis (ADCP) Apoptosis Direct effects Immunomodulatory effects These mechanisms may contribute to the development of resistance to CD38 antibodies
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