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They observed that quercetin was effective in attenuating inflammation and reducing arteriole thickness, as well as increasing miR-204 expression, a small non-coding RNA that has been associated with tumor suppression tumor and increased susceptibility to chemical treatments [243] Moreover, quercetin also decreased gene and protein expression of Poly ADP-ribose polymerase-1 (PARP1), a repair protein that is activated due to DNA damage in severe inflammation, hypoxia-inducible factor 1-alpha (HIF1α), nuclear factor of activated T-cells cytoplasmic 2 (NFATc2), and α-Smooth muscle actin (α-SMA), which are associated with apoptosis resistance and proliferation [241]

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doi: 10.1007/s12035-014-8750-5