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E3 is also a component of a fourth mitochondrial multienzyme complex, the glycine cleavage system, where it functions as the L protein, a housekeeping enzyme that, to date, has not appeared to impair the function of the system in vivo when associated with pathogenic variants of DLD [143]
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Notably, while only ~5–10% of the general population carries these antibodies, an estimated 50–70% of children with autism may have folate receptor antibodies [3]
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