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Glossitis and hyperpigmentation of hands due to Vitamin B12 deficiency. ⬇️ B12 leads to ⬆️ melanin synthesis more frequently in people with darker skin. Skin hyperpigmentation was reversed with B12 replacement

Generally, the modulation of these processes begins with the activation of G-protein coupled receptors (GPCRs) in the somatotrophs ( Figure 2 )

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