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Early studies of 11C-PIB uptake in PD suggested very little difference from controls 211,212 , and in a meta-analysis, while high beta-amyloid positivity was seen for DLB and PDD compared to controls, the positivity rate in PD was actually lower than in controls 213
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Thus far, only one 2025 clinical trial has evaluated the efficacy of a plant compound, namely curcumin, against CIPN using the gold-standard randomised, double-blind, placebo-controlled design
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