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Cell membranes are phospholipid bilayers with extrinsic proteins and are direct targets of lipid oxidation
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By promoting oxidative stress, NOX4 induces the production of the lipid peroxidation end-products, such as 4-hydroxynonenal (4-HNE) and malondialdehyde, and ultimately mediating ferroptosis-dependent cytotoxicity of astrocytes in AD 105
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