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Nitric Oxide produced by a nitric oxide synthase reacts with... | Download Scientific Diagram
doi:10.1093/jn/137.6.1549S
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Consequently, various biomechanical analyses have shown that diabetic bone derived from humans and rodent model studies are accompanied by increased fragility and fatigue, with reductions in crucial parameters, such as mechanical load, elasticity, energy absorption and stiffness ( Impaired bone healing observed in individuals with T2DM is a multifactorial phenomenon, affecting all stages of bone repair and mediated by numerous initiators, including hyperglycaemia, chronic inflammation, oxidative stress, advanced glycation end products (AGEs), polyol pathway, high protein kinase C (PKC) activity and hexosamine biosynthesis pathways
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