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The actin-sequestering mechanism Tβ4’s defining biochemical activity was established by Safer, Elzinga and Nachmias in 1991, who showed that the previously characterized actin-sequestering peptide "Fx" was sequence-identical to Tβ4 and forms a 1:1 complex with G-actin monomers , inhibiting their polymerization into F-actin filaments (Safer, Elzinga & Nachmias, 1991)
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