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SCFA dynamics and neurotrophic signaling under high-altitude hypoxia SCFAs are key metabolites of beneficial gut bacteria, and their availability under high-altitude hypoxia may be influenced by shifts in SCFA-producing taxa: while several genera such as Bifidobacterium , Agathobacter , and Collinsella are depleted in Han migrants during high-altitude exposure, the SCFA-producing families Ruminococcaceae and Lachnospiraceae , along with microbial BCoAT gene abundance, are enriched in high-altitude-adapted populations (Zhao et al., 2024)

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