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This compound, which was termed Ferroptosis-Inducer-56 (FIN56), induces the degradation of GPX4 and also acts through the mevalonate pathway to drive increased sensitivity to ferroptosis by depleting CoQ 10
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However, increased GSNO levels have been observed in inflammatory states and subsequent induction of inducible nitric oxide synthase (iNOS), which is also related to hypertension (32)
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