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For example, it has been identified that there is global hypermethylation of DNA in PBMCs, particularly in regions related to the increase of IL-10 in vitiligo patients (Zhao et al., 2010)
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PATHOPHYSIOLOGY The pathophysiology of hyperbilirubinemia in GS is multifactorial[11,12], involving disruptions in bilirubin production, hepatic uptake glucuronidation, and transport, all influenced by genetic factors (Figure 1)
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