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Conversely, when GPX8 is silenced, the histamine-induced release of Ca 2+ from the endoplasmic reticulum to mitochondria and cytoplasm is increased (Yoboue et al., 2017)
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Microglial activation can also disrupt the behavior of the astrocytes [217], which in turn can further disrupt glutamate homeostasis, upset GABA regulation, and neuronal pruning [196]
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