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It plays a key role in the metabolism of fatty acids and amino acids, supporting normal energy production at the cellular level.* Nervous system function — Methylcobalamin is critical for the maintenance of the myelin sheath — the protective coating around nerve fibres — supporting healthy nerve conduction and normal neurological function.* Methylation & homocysteine metabolism — B12 is a key cofactor in the methylation cycle, the biochemical pathway responsible for converting homocysteine to methionine

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However, a recent study from March of 2026 found that an 8g dose of citrulline malate failed to improve leg press strength or repetitions compared to placebo, while another group taking 12g saw improvements.25 The cohort was all trained individuals, which may be important