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The SFN (5 μM) pretreatment in SH-SY5Y induced with 6-OHDA (100 μM), showed more increase in the active nuclear Nrf2 protein and also a more reduction of apoptosis compared to erucin (5 μM) treatment
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In addition, most current safety evaluations of AS-IV are based on systemic administration models, with no toxicity dose testing specifically targeting the liver (206)
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