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(3) the Broad-Spectrum Attempts (2000s-2020s), which encountered clinical failures in non-APL malignancies due to the absence of analogous targets, deficiency of the metabolic activation enzyme AS3MT [arsenic(+3 oxidation state) methyltransferase], and robust efflux/antioxidant defenses
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Many in vivo studies involving cyclophosphamide-induced interstitial cystitis have confirmed these findings
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