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In RA (rheumatoid arthritis), where the expression of GPx4 is elevated and the level of promoter methylation is altered, glycine can promote the methylation of GPx4 promoter by elevating the concentration of SAM (S-adenosylmethionine) promotes GPx4 promoter methylation and reduces its expression, which in turn enhances ferroptosis in fibroblast-like synoviocytes and attenuates synovial hyperproliferation and inflammatory injury, whereas Jinwu Jianbao capsule improves RA symptoms by inhibiting ferroptosis through modulation of the SLC7A11/GSH/GPx4 pathway
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