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These findings not only supported the importance of endogenous GSTP in protecting against excessive inflammation but also the potential therapeutic effects of recombinant GSTP protein on sepsis
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The activation of SIRT1 by RES is closely linked to the adenosine monophosphate kinase (AMPK) pathway, where AMPK increases nicotinamide phosphoribosyltransferase (NAMPT) expression, raising intracellular NAD levels and further activating SIRT1 [36]
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