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Intriguingly, NNT silencing also promoted mitochondrial membrane hyperpolarization, increased oxygen consumption and ATP production, and diminished lactate production, implying a metabolic shift from glycolysis to mitochondrial OXPHOS to correct the accumulation of NADH in these cells
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654-657 However, many of these trials used relatively low doses (eg, the equivalent of about 2,000 IU [50 mcg] per day or less) and/or high intermittent doses rather than regular daily doses
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