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Activity of ACE was determined by measuring the formation of angiotensin II after addition of angiotensin I in the presence and absence of an ACE inhibitor and a chymase inhibitor to determine the ACE-inhibitor sensitive fraction of angiotensin II generation

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57 As many MPNSTs in NF1 patients have mutations in components of the PRC2 complex, which negatively regulates gene expression through histone methylation (H3K27Me) resulting in histone acetylation (H3K27Ac), inhibiting BRD4 might be particularly effective

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