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Loss of AT-Rich Interactive Domain 1A Expression in Gastrointestinal Malignancies
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When titrating SmTrx to the U597C enzyme we observe a slowing in rate of the first reoxidation event, which approaches the rate of turnover of the enzyme with Trx as the oxidant (from ∼2 s −1 to ∼0.12 s −1 ), and a complete loss of the second slower reoxidation event
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