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Under hypoxia, acrolein produced in glioma cells inhibits neutrophil activation and induces neutrophil polarization to the N2 phenotype to produce Arginase‐1 (ARG‐1) in vitro, which promotes the progression of glioma by directly reacting with the Cys310 residue of AKT to inhibit AKT activity [71]
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GPNMB gene expression was markedly upregulated in macrophages isolated from liver tissues of NASH model mice compared to that of normal diet group
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