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Previous research has implicated hyaluronan as a potential therapeutic capable of both stimulating and inhibiting angiogenesis depending on its form and concentration [287, 288]

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(achromachia): abnormally long, slender fingers and toes Pectus deformity Pectus carinatum: a sternal deformity where the middle and lower portion of the sternum protrude forward (also known as sternal kyphosis) Pectus excavatum: a sternal deformity where the middle and lower portion of the sternum protrudes inward Pes planus (flat foot) or hindfoot valgus Spinal deformities (scoliosis, hyperkyphosis) Vertical overdevelopment of the head (dolichocephaly) Winged scapula Habitual dislocations (particularly the patella and shoulder) Acetabular protrusion Skin Hyperextensive skin Formation of striae (stretch marks) Eyes Visual impairment: ectopia lentis (lens dislocation) → lens subluxation superiorly and temporally Severe myopia Retinal detachment Glaucoma Early cataract formation Other Increased risk of spontaneous pneumothorax Lumbosacral dural ectasia The classic presentation of MFS includes aortic aneurysm or dissection, long extremities, arachnodactyly, joint hypermobility, and subluxation of the lens of the eye