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Furthermore, sea buckthorn fruit extract, identified as a citric acid derivative, inhibited LPS-induced NO production in RAW 264.7 cells by inhibiting the expression of IκB kinase alpha/beta (IKKα/β), inhibitor of kappa Bα (I-κBα), NF-κB p65, iNOS, and COX-2, and the activities of interleukin 6 (IL-6) and TNF-α (79)
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