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Recent studies have found that trihydroxychalcone is a treatment for AD by simultaneously inhibiting Aβ 1 – 42 aggregation and ferroptosis (Cong et al., 2019), and ferroptosis-specific inhibitor Fer-1 can inhibit the accumulation of ROS/RNS and reduce the accumulation of α-synuclein under rotenone-induced oxidative stress, then protect neuroblastoma cells SH-SY5Y (Kabiraj et al., 2015)
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