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CLDN-2, CLDN-4 and JAM-1 expression was increased in 0.8 mM GDC –treated monolayers ( P 0.05)

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Of these, two meta-analyses found a statistically significant mortality benefit [36,41], five did not discuss mortality [33,34,39,42,43], and eleven failed to find a significant mortality reduction [35,37,38,40,44–49,66]