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A 2023 study by Wattez, Eury, Hazen, and colleagues in Molecular Metabolism demonstrated that skeletal-muscle-specific combined ERRα/γ double knockout produced pale, oxidatively impaired muscles and severe exercise intolerance in mice — with dmKO animals unable to switch to lipid utilization during running — establishing that ERR activity is necessary for normal aerobic capacity
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Complications Over time, MS can lead to a number of complications, which vary widely between individuals
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