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FDA • Generic name: Enlicitide • Brand name: Lipfendra™ • Once-daily oral tablet (20 mg) • Increases LDL receptor recycling by inhibiting PCSK9, resulting in enhanced LDL cholesterol clearance • Demonstrated approximately 56–59% LDL-C reduction in Phase 3 clinical trials Indications ✔️ Primary hypercholesterolemia ✔️ Heterozygous familial hypercholesterolemia (HeFH) ✔️ Adults requiring additional LDL-C reduction despite maximally tolerated statin therapy This approval marks an important advancement in cardiovascular pharmacotherapy and highlights how innovation continues to improve treatment options for patients at high cardiovascular risk