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Most importantly, so far, almost all genes that participate in ferroptosis are involved in the transcriptional regulation of NRF2, including glutathione regulation (such as System X c − and GPX4), iron regulation (such as FTH1 (ferritin heavy chain 1), FTL (ferritin light chain) and FPN1 (ferrous iron exporter ferroportin 1)), NADPH regeneration (such as G6PD (glucose-6-phosphate dehydrogenase), and ME1 (malic enzyme 1)), and so on [11,12,13,14], which are described in this review too

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Interestingly, some studies suggested that—besides the Rag-TSC interaction—TSC binding to membrane-bound RHEB is also contributing to its recruitment to lysosomes upon growth factor or arginine removal (Menon et al., 2014