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It is evaluated that half of all drug candidates are substrates for the P-gp efflux pump, presenting a reduced potential for systemic penetration to the CNS [7]
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Furthermore, this novel concept suggests that the GLP-1 analog could spare the pasireotide-induced decrease in endogenous GLP-1 concentrations and recover insulin secretion suppressed by pasireotide through GLP-1R-Gs activation counteracting the SSTRs-Gi axis
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