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Such diversity is highly unusual among Eukaryotes: a canonical arrangement has been conserved in GS enzymes for ~1 billion years of evolution in three kingdoms of life (Fig 5, Plantae (St-GSS1-closed, PDB 5OES), Fungi ( Saccharomyces cerevisiae , PDB 1M0T), and Animalia ( Homo sapiens GSS1, PDB 2HGS))
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