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Choice C: Preformed antibodies in the donor would be diluted in the recipient's circulation and do not cause graft-versus-host disease
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2.4.6 PI3K/AKT and Sirtuin1 The autophagy-lysosomal pathway is responsible for maintaining the metabolic balance of the ECM by sequestering FN within the cytosol and activating lysosomes for degradation in fibrosis ( SalB can also ameliorate autophagy and upregulate Sirtuin1, which can both lessen renal pathological damage and improve renal insufficiency (Pan et al., 2011
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