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Not only are laboratory rats bred to be healthy under standard laboratory conditions, potentially reducing the genetic factors making them susceptible to disease, they are also fed an exceedingly healthy diet [2] and are often largely free of infections, environmental toxins, and other oxidative stress factors associated with ASD in humans

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This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Similar content being viewed by others Data availability CRISPR screen raw data have been deposited to GEO (GSE302082)